Gogi Mikeladze mastered the art of film production design at the Painting Department of the Tbilisi Academy of Arts (1965 – 1971). After his graduation, he got involved in the projects of Georgian Film Studio. He is the production designer of many famous and popular Georgian films, including  The Armchair by Eldar Shengelaya (2016), Someone Else’s House by Rusudan Glurjidze (2014),  Rene Goes to Hollywood by Tsabadze (2007),  Comrade Stalin Journey to Africa  (1989)  by  Irakli Kvirikadze,  Repentance by Tengiz Abuladze (1983),  Day is Longer than Night (1982) by Lana Gogoberidze,  Three Days of Hot Summer by Merab Kokochashvili (1980),  The City of Anara by Irakli Kvirikadze (1976),  Seedlings by Rezo Chkheidze (1971) ), etc. It was with Seedlings that he began his collaboration with the Georgian Film Studio which continues to this day.

In 1987, the film Repentance was awarded the Russian Film Academy Prize Nika in the nomination for Best Production Design.

Georgy Mikeladze twice became a laureate of the State prize: first in 1987, for the design of Nodar Managadze’s film Hey, Maestro! and in 2004 For the M.  Borashvili’s movies   The Path of the Savior and Oh, Mother of God!

Gogi Mikeladze participated in pop-art exhibitions held in Tbilisi and Moscow in 1986, and the group exhibitions in Warsaw, Lausanne, Munich, and other European cities that took place in 1979-1994.

In 1995, he had personal exhibitions in Berlin, and then, in  1999, in the city of Pittsburgh (Pennsylvania, USA).

Goga Mikeladze’s works are kept in private collections in Japan, Belgium, Italy, France, Russia, and Georgia; about twenty works were acquired by the Zimmerli Museum in New Jersey, whose founders collected a large collection of Soviet non-conformist art back in the Soviet period.

In his artwork, the artist uses elements of pop art while creating collages and art objects.