Painter, teacher, and honored artist of Georgia, Nana Meskhidze grew up in an artistic environment. Her father was a musician and choirmaster, and her mother was an actress at the Marjanishvili Theatre in Tbilisi.

In 1963, she graduated from the Tbilisi Academy of Arts, where she mastered painting under the well-known Georgian painter Ucha Japaridze.

While teaching painting at the Tbilisi Nikoladze Art College, in 1965 she joined the Georgian Union of Artists and started participating in numerous local and union-scale shows.

Among her most notable works are A Sister and a Brother (1963), My Father (1965), Victory Day (1970), The Tennis Players (1971), and Actors Behind the Scenes (1975).

Her painting The Mothers, preserved at the Georgian National Gallery, is considered one of the best in her oeuvre.

Paintings by Nana Meskhidze are preserved in various galleries in Georgia and Russia.